The Russian Federation Ministry of Atomic Energy (Minatom) is the federal authority empowered with the management of state-owned nuclear materials, with the exception of military applications. The Russian Federal Nuclear Materials Control and Accounting Information System (FIS) is a key component in establishing an effective nuclear materials management system in the Russian Federation. In December 2000, the Russian government issued the decree to enter into force the regulation on the accounting and control of nuclear materials and directed the State System of Accounting and Control (SSAC) of nuclear materials should begin October 2001. This regulation establishes the basic accounting documents and the requirement to report them to the FIS to launch the State Nuclear Material Registry of nuclear materials. The Nuclear Material Registry contains information on agencies and operating organizations that use nuclear material, along with the kinds, quantity and other characteristics of nuclear material. . This paper discusses the role and the place of the FIS in nuclear material management, describes the goals and challenges facing the FIS based on Russian Federation regulations, and provides a brief description of the Nuclear Material Registry and the procedures used in its creation.