Recent measurements of J/(psi) production in e(sup +)e(sup -) colliders pose a challenge to the NRQCD factorization theorem for quarkonium production. Discrepancies between leading order calculations of color-octet contributions and the momentum distribution of J/(psi) observed by Belle and BaBar are resolved by resumming large perturbative and nonperturbative corrections that are enhanced near the kinematic endpoint. The large cross sections for J/(psi) + c + (bar c) and double quarkonium production remain poorly understood. Nonperturbative effects in fixed-target hadroproduction of open charm are also discussed. Large asymmetries in the production of charm mesons and baryons probe nonperturbative corrections to the QCD factorization theorem. A power correction called heavy-quark recombination can economically explain these asymmetries with a few universal parameters.