The purpose of this project was to explore and refine applications of isotope ratio measurements for guiding environmental remediation strategies. The isotopic compositions of samples collected from field sites were analyzed to address both basic scientific issues and site-specific problems. The Test Area North (TAN) site at INEEL consists of a 2 km-long plume of mixed wastes containing low-level radionuclides, sewage and chlorinated solvents that were injected into the groundwater between 1955 and 1972. Measurements were made of the hydrogen, carbon, oxygen and strontium isotopic ratios of groundwater samples to address questions about the source of the groundwater and the regional hydrology of the area.