Protein Nucleic Acid Interactions (Final Report, 1999-2004).

Berman, H. M. ; Thornton, J.

Technical Information Center Oak Ridge Tennessee

关键词: Proteins;    Nucleic acids;    Genes;    Molecular interactions;    Molecular structure;   

RP-ID  :  DE2006836885

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

The overall goal of this collaborative project is to develop methods for analyzing protein-nucleic acid interactions. Nucleic acid-binding proteins have a central role in all aspects of genetic activity within an organism, such as transcription, replication, and repair. Thus, it is extremely important to examine the nature of complexes that are formed between proteins and nucleic acids, as they form the basis of our understanding of how these processes take place. Over the past decade, the world has witnessed a great expansion in the determination of high-quality structures of nucleic acid-binding proteins. As a result, the number of such structures has seen a constant increase in the Protein Data Bank (PDB) (1) and the Nucleic Acid Database (NDB) (2). These structures, especially those of proteins in complex with DNA, have provided valuable insight into the stereochemical principles of binding, including how particular base sequences are recognized and how the nucleic acid structure is quite often modified on binding.