Fluid-structure interaction is a cause of failures experienced in fuel rods and is of particular importance for all reactor components in Generation IV reactors which unanimously adopt a pool configuration. A Nuclear Energy Research Initiative (NERI) project proposal has been submitted to United States Department of Energy (USDOE) to develop an advanced design methodology to model fluid-structure interaction, predict its consequences, and guide the design methodology to model fluid-structure interaction, predict its consequences, and guide the design of reactor components. The proposed design methodology is an integrated experimental/theoretical/numerical technique. Preliminary studies have been performed utilizing the CFD code STAR-D coupled to a first-order structural mechanics model to explore the issues of coupled dynamic fluid/structure interactions-flow field, fluid forces, and instability of tubes-in the cross flow regime.