Sandia National Laboratories is currently exploring opportunities to apply its modeling and simulation (M&S) capabilities to support a wide spectrum of DoD needs. Joint Vision 2010 served as the template for five different M&S thrust areas. One of the operational concepts of JV 2010 is Full-Dimensional Protection which is the control of the battlespace to ensure freedom of action during deployment, maneuver and engagement; while providing defenses for forces and facilities. From this concept we have identified a number of force protection needs and are evaluating Sandia M&S tools and concepts in relation to these needs. Within the trust area of force protection we have identified a number of M&S opportunities. They include risk analysis and vulnerability assessments using tools such as HAMER (Hazard Assessment and Mission Enhancement of Resources) and other force protection database and management systems. For the Chem-Bio threats, work is ongoing to model dispersion of airborne chemical/biological agents in relatively open areas and also in complex structures. Models have also been developed to simulate the blast response by structures. Other areas include the use of physics-based modeling and simulation methods, intelligent adaptive algorithms and cognitive engineering to develop predictive tools, global optimization of problem solutions and advanced learning methods. This paper will briefly discuss some of the M&S capabilities and opportunities to meet DoD force protection needs.