Thick-target neutron yields and energy spectra from (alpha,n) reactions in honogeneous media calculated with ORIGEN-S and SOURCES were compared. SOURCES calculates yields and spectra from fundamental physics and data and is applicable to any combination of alpha-particle slowing-down, emitting, and target elements. ORIGEN-S employs approximations for both its UO2 and borosilicate-glass options that limit its applicability. Yields from both ORIGEN-S options compare favorably with yields from SOURCES. For UO2-like slowing down media, spectra using the UO2 option compare moderately well with SOURCE spectra. ORIGEN-S with the borosilicate-glass option is often employed for any non-UO2-like slowing down media to generate spectra, but any agreement with SOURCES spectra is conincidental.