The U.S. effort to develop nuclear waste partitioning and transmutation systems is described. This effort has evolved since the 1999 ATW Road Map to include the possibility of Multi-tier transmutation systems in which much of the plutonium could be fissioned in thermal spectrum power reactors. A set of transmutation system objectives that is being used to cross compare technology options is described. Technology development plans, consistent with the multi-tier approach, are discussed. An assessment of the available infrastructure of people with appropriate expertise and facilities with needed capabilities indicates that emphasis on international collaborations and university involvement will be essential to program success. An integrated test facility, envisioned to provide the ultimate proving ground for transmutation technologies, is also discussed briefly.