Transverse loading experiments on wire has shown that a significant drop in critical current occurs for stresses greater than 50 MP-a. However, many high-energy physics applications require that the Bi2Sr2CaCu2O8 conductor withstand stresses greater than 10 MP-a without permanent degradation. Therefore, a study of epoxy impregnated cables, identical to those used in accelerator magnet applications, has been performed. This work presents the first results of Rutherford cable of Bi2Sr2CaCu2O8 with transverse stress. The results show that the cable can withstand stresses up to 60 MP-a with a strain of about 0.3% for the face loading orientation and 100 MP-a for the edge loading orientation.