Events with signatures involving large missing transverse energy (E(sub T)) are among the quintessential search modes for R-parity conserving supersymmetry. CDF has conducted two recent analyses for supersymmetry which use E(sub T) and jets. The E(sub T) and monojet signature is employed to determine process independent limits for the production of new physics beyond the Standard Model and then applied to models of spontaneous breaking of supersymmetry to determine limits on the supersymmetry breaking parameter and the gravitino mass. Direct searches for scalar top and scalar bottom quarks within the framework of supersymmetric models are performed using a signature of E(sub T) and two heavy flavor jets.