Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae

Overbey, Eliah G ; Paul, Amber M ; Silveira, Willian A da ; Tahimic, Candice GT ; Reinsch, Sigrid S ; Szewczyk, Nathaniel ; Stanbouly, Seta ; Wang, Charles ; Galazka, Jonathan M ; Mao, Xiao Wen

关键词: ADAPTATION;    ASTRONAUTS;    BRAIN;    CENTRAL NERVOUS SYSTEM;    EXPOSURE;    GENE EXPRESSION;    HYPOTHESES;    MICROGRAVITY;    RISK ASSESSMENT;    SPACE FLIGHT;   

RP-ID  :  ARC-E-DAA-TN75608

学科分类：生物科学（综合）

美国|英语

来源: NASA Technical Reports Server

【 摘 要 】

A combination of spaceflight-relevant factors (fluid-shift and radiation) created a different gene expression profile than either factor individually. Some gene pathways including reduced transcriptional machinery, increased neurogenesis and neuropeptide production, and dysregulated cell structure and cell signaling. Gene expression differences can persist for at least 4 months after a 21- day exposure to a combination of fluid-shift and radiation in the brain tissue of mice. Brain-related transcriptional changes are dynamic during readaptation phase from exposure to spaceflight-like conditions, which may lead to long-term neurological consequences.