Infrared telescopes are a powerful tool to probe a wide range of environments in the universe in order to understand how galaxies evolved over billions of years, how stars and planets form, and how life came to be. Observing in the infrared enables detecting the faint heat signals emitted by these far-distant objects, providing unique insights into the physical processes leading to the evolution of the universe and its contents.This presentation will provide an overview of some of the NASA missions under development, which aim to design, build and operate state-of-the art telescopes to address such scientific questions. Emphasis will be given to the James Webb Space Telescope, the technological challenges encountered during its realization and the countless spin-offs it has generated, which benefit life on Earth every day. My specific contributions to this project, as well as those from some ISAE-SUPAERO students who have worked with me, will be briefly highlighted.