Human missions to Mars present several major challenges that must be overcome, including delivering multiple large mass and volume elements, keeping the crew safe and productive, meeting cost constraints, and ensuring a sustainable campaign. Traditional methods for executing human Mars missions minimize or eliminate in-space assembly (iSA), which provides a narrow range of options for addressing these challenges and limits the types of missions that can be performed. This paper discusses recent work to evaluate how the inclusion of in-space assembly in space mission architectural concepts could provide novel solutions to address these challenges by increasing operational flexibility, robustness, risk reduction, crew health and safety, and sustainability. Several assembly focus areas identified through previous work were developed and evaluated to identify high-potential iSA applications that can have meaningful impacts on the challenges facing Mars missions. Architecture trade options were developed and assessed through sensitivity analyses, resulting in identification of six iSA-based architecture solutions that could be incorporated into Mars mission architectures with moderate levels of assembly. Assembly agent and infrastructure concepts were also developed that would be necessary to enable or facilitate the iSA operations. Several observations developed through the study are presented to inform future human mission architecture and campaign developments.
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