The Zero-Boil-Off Tank (ZBOT) experiments are a series of small scale two-phase fluids physics experiments conducted aboard the International Space Station (ISS) in 2017. A goal of these experiments is to study various fundamental fluid flow, heat and mass transport, and phase change phenomena that control storage tank pressurization and pressure control in microgravity. In this paper, results of a state-of-the-art two-phase CFD (Computational Fluid Dynamics) storage tank model are presented and validated against jet mixing data provided by microgravity ZBOT experiments. Jet-ullage interaction was studied in the experiment for different jet speeds representing different flow regimes, and tank fill levels. Effects of various physical parameters, such as, jet angle, gravitational acceleration and surface tension value were investigated. Computational parameters, such as turbulence and surface tension models and interface capturing scheme, affecting jet-ullage interaction were also studied. Computational results were compared to experimental results for model validation.