As a consequence of planned/proposed human lunar activity, the long-term effects of lunar debris and ejecta resulting from large-body (> 1000 kg) impacts on the lunar surface is investigated. The Escape-Velocity-Domain (EVD) ejecta behavior is characterized in terms of destination, duration in lunar orbit, and total displaced mass. Likewise, the amount of mass sent into geosynchronous orbit is also characterized and assessed as a function of impact location in terms of Sun-Earth-Moon angle, lunar latitude and longitude, and impact angle. Finally, a threat analysis is performed on critical assets in Earth and Lunar orbit such as the I.S.S., geosynchronous satellites, prospective lunar base, and the Deep Space Gateway now under construction.