Networking between ISS payloads and the ground presents challenges given the delays in communication and frequent satellite handovers that occur in orbit. Delay Tolerant Networking (DTN) provides a method to store and forward information when the link is available without intervention by the user. While DTN is helpful for the ISS in Low Earth Orbit (LEO), it will become much more important for deep space missions where round trip delays make use of most standard network protocols impossible. The lessons learned from ISS and other programs will help improve standards and ultimately support future NASA deep space missions.