NAI Supported Research, a Case Study: the Origin of Protein Functions

Pohorille, Andrew

关键词: BIOLOGICAL EVOLUTION;    COMPUTERIZED SIMULATION;    ENZYME ACTIVITY;    HYDROPHOBICITY;    IN VITRO METHODS AND TESTS;    MUTATIONS;    POLYPEPTIDES;    PROTEINS;    RIBONUCLEIC ACIDS;    STRUCTURAL STABILITY;    WATER;   

RP-ID  :  ARC-E-DAA-TN70059

学科分类：生物科学（综合）

美国|英语

来源: NASA Technical Reports Server

【 摘 要 】

In the 20 years of its existence, the NAI supported a host of studies that fundamentally advanced the field of astrobiology in terms of both understanding the underlying concepts and developing novel research techniques. In this presentation, I will recount one such case in the field of the origin of life, whereby application of new, powerful experimental techniques combined with state-of-the art computer simulations led to a surprising insight into the origin of protein functions.