A scale model of a NASA representative space vehicle is used to develop a refined estimate of the transient pressure loads that are expected to form at the base of the vehicle in the event of a vapor cloud explosion. Flammable vapor clouds are known to form prior to engine startup due to the significant amount of unburned hydrogen that is ejected from the combustion chamber. In the event of a vapor cloud explosion, the vehicle and payload must be able to withstand the resulting overpressure waves. The study comprises an array of pressure sensors located along the base heat shield of the scale model space vehicle as well as the interior wall and throat plug plane of the solid rocket booster. A spark source generator is used to simulate the overpressure wave produced by a vapor cloud explosion while measurements are acquired with and without the effect of a mobile launcher. Time- resolved schlieren images of the simulated vapor cloud explosion reveal the path and impact of both the initial wave and several reflected waves on the various components at the base of the space vehicle. In some instances, the reflected waves superpose to create waves that are higher in amplitude than the initial overpressure wave. A time frequency analysis of the pressure waveforms measured inside the solid rocket booster reveal a ring down tone corresponding to a standing wave that is four times the length of the nozzle.