NASA has identified potential damage from micrometeoroid and orbital debris (MMOD) impacts as a primary threat to Commercial Crew Program vehicles. The International Space Station (ISS) and extraterrestrial habitats also exhibit the risk of damage caused by MMODs. Currently no integrated in-situ or real-time health monitoring damage detection system is being used for expandable and inflatable structures. A novel, modular damage detection system design that incorporates interchangeable and replaceable sensory panels in a foldable architecture is described. The design implements technologies that provide for situational awareness, self-configuration, and damage detection and localization. The system is applicable for the new Gateway and surface and ground support infrastructure