Aerospace is in the midst of a renaissance, expanding on both the air and space side into major new commercial areas including unmanned air systems (UAS), on demand mobility (ODM), personal air vehicles (PAV), and commercial deep space. These new areas require, in the initial planning, consideration of new safety, reliability, and in some cases, enabling performance approaches for viability. For example, due to their huge numbers, if current accident rates prevail, UAS/ODM/PAV aircraft could crash at an unacceptable rate, causing life and property damage. Also, if humans in commercial space activities have serious health issues and/or there are unacceptable rocket viability issues/crash rates, these new, major markets (order of 1 trillion dollars per year) could be rapidly curtailed until agreeable and effective changes are instituted, producing additional expense, delay, and reduced revenue. This report addresses such safety and reliability issues and includes: performance enhancement possibilities such as an enabling Air Traffic Control System (ATC), crash proof vehicles, increased range for aero, space debris removal, and human health for space.