科技报告详细信息
The Role of Gravity Mechanotransduction in Regulating Stem Cell Tissue Regenerative Potential at the Single Cell Expressome Level
Juran, Cassandra M ; Zvirblyte, Justina ; Coyne, Molly ; Almeida, Eduardo A C
关键词: STEM CELLS;    BONE MARROW;    ORGANISMS;    PHOSPHORYLATION;    SEQUENCING;    SPACE FLIGHT;    CELLS (BIOLOGY);    COLLAGENS;    GENE EXPRESSION;    GLYCOLYSIS;    GRAVITATIONAL EFFECTS;    LOCOMOTION;    MITOSIS;    MORPHOLOGY;   
RP-ID  :  ARC-E-DAA-TN62941
学科分类:生物科学(综合)
美国|英语
来源: NASA Technical Reports Server
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【 摘 要 】

Gravity is an omnipresent force on Earth, and all living organisms have evolved under the influence of constant gravity. Mechanical forces generated by gravity are potent modulators of stem cell based tissue regenerative mechanisms, inducing cell fate decisions and tissue specific commitment. A novel mechanical unloading investigation assessed the formation, morphology, and gene expression of embryoid bodies (EB), a transitory cell model of early differentiation. After 15 days of spaceflight, the mechanotransduction-null EB cells showed upregulated proliferative mechanisms while differentiation cues were silenced.

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