Urban Air Mobility (UAM) vehicles will need to meet the safety and comfort expectations of passengers and crews. However, existing Federal Aviation Administration airworthiness standards for airplanes and rotorcraft are unlikely to adequately address these needs. Some insight into this issue may be gained from research into NASA's approach to human-systems integration standards and guidelines that promote astronaut health, safety, and performance, since both space and UAM vehicles must consider factors such as occupant motion sickness, vibration, and sound levels. Building upon knowledge garnered from the experience of NASA, the U.S. Department of Defense, and other international organizations, this presentation will elucidate: 1) how UAM-induced flight factors can impact occupant comfort, productivity, as well as safety; and 2) how government and industry standards could be developed or revised to help assure passenger acceptance of revolutionary Vertical Take Off and Landing aircraft technologies.