Multistage Delivery of Active Agents

Ferrari, Mauro [Inventor]Tasciotti, Ennio [Inventor]Sakamoto, Jason [Inventor]

关键词: DISEASES;    DRUGS;    IMAGING TECHNIQUES;    MOLECULAR STRUCTURE;    NANOPARTICLES;    RADIATION THERAPY;    RESERVOIRS;    TARGETS;    THERAPY;    PATENTS;    CANCER;    HEALTH;    INFECTIOUS DISEASES;    NANOTECHNOLOGY;    SEMICONDUCTORS (MATERIALS);    SILICON DIOXIDE;   

RP-ID  :  US-Patent-10,143,658, US-Patent-Appl-SN-14/725,570

学科分类：生物科学（综合）

美国|英语

来源: NASA Technical Reports Server

【 摘 要 】

Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.