Long-term data records obtained from Earth observing sensors depend not only onthe calibration accuracy of individual sensors but also on the consistency across instruments andplatforms. Hence, sensor calibration intercomparison plays a vital role for a better understandingof various science products. The Moderate Resolution Imaging Spectroradiometer (MODIS)and enhanced thematic mapper plus (ETM+) on the Terra and Landsat 7 platforms have operatedsuccessfully since their launch, collecting measurements in the reflective solar and infrared partsof the spectrum. Terra MODIS has employed a reflectance-based calibration since beginning itsmission. In the case of ETM+, a radiance-based calibration was employed until recent years,when a reflectance-based calibration was introduced. Being in the AM constellation with lessthan 30 min difference in overpass times, near-simultaneous Earth scene measurements can beeffectively used to assess the calibration differences between the spectrally matching bands ofthese two instruments. The pseudoinvariant calibration sites (PICS) in the North African desertare widely used for on-orbit calibration and validation of satellite sensors. Four PICS from thisregion have been employed to assess the multitemporal reflectance differences. Correction forbidirectional reflectance, spectral response function mismatch, and impacts of atmosphericwater-vapor have been incorporated to provide an assessment of the long-term stability ofeach spectral band and reflectance differences amongst them. Results indicate that the spectralbands of both instruments show a long-term stability to within 2% from 2000 to 2017. Thetop-of-atmosphere reflectances between the two instruments postcorrection agree to within 4%.Also included in this paper is a detailed discussion of various parameters contributing to theuncertainties of this cross-calibration. The techniques presented in this paper can be furtherextended to perform similar intercomparison between Landsat 8 Operational Land Imager, AquaMODIS, and Suomi-NPP VIIRS.