Probabilistic Risk Assessment (PRA) has been applied in different industries for many years. Each industry and technology area presents varying challenges and priorities, and the risk models therefore need to be somewhat different. This paper compares aspects of risk modeling of offshore drilling, nuclear plant operation, and human spaceflight. Risk models in all three technology areas have certain high-level similarities: (1) they employ redundancy and diversity in their means to prevent or mitigate risk, including a mix of active and passive systems designed to respond to off-normal evolutions; (2) they are affected by human reliability; (3) their models require consideration of coupling between scenario structure and scenario phenomenology. But in examining the models in more detail, one sees important differences in methodology and emphasis. For purposes of comparison, this paper discusses aspects of a risk model of an offshore drilling operation in the U.S. Gulf of Mexico, focusing on where such a development differs in important ways from models of commercial U.S. nuclear plants and models developed for human spaceflight.