Determining the biological impact of spaceflight through novel approaches is essential to reduce the health risks to astronauts for long-term space missions. The current established health risks due to spaceflight are only reflecting known symptomatic and physiologic responses and do not reflect early onset of other potential diseases. There are many unknown variables which still need to be identified to fully understand the health impacts due to the environmental factors in space. One method to uncover potential novel biological mechanisms responsible for health risks in astronauts is by utilizing NASA's GeneLab Data Systems (genelab.nasa.gov). GeneLab is public repository that hosts multiple omics datasets generated from space biology experiments that include experiments flown in space, simulated cosmic radiation experiments, and simulated microgravity experiments. This presentation will provide an overview of GeneLab and examples of analysis that are being done with GeneLab datasets. These example will include novel data and work being generated with various scientists around the world involved with GeneLab's Analysis Working Groups (AWG) that are assisting with the development of pipelines and advancing GeneLab to the next phase, a publication from GeneLab discovering novel Carbon Dioxide impact due to rodent habitats, another publication from GeneLab discovering a potential master regulator responsible for health risk associated due to spaceflight, and potential cardiovascular risk from space radiation.
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