A noise reduction technology roadmap study is presented to determine the feasibility for the Mid-Fuselage Nacelle (MFN) aircraft concept to achieve the noise goal set by NASA for the Far Term time frame, beyond 2035. The study starts with updating the noise prediction of the existing MFN configuration that had been modeled for the time frame between 2025 and 2035. The updated prediction for the Mid Term time frame is 34.3 dB cumulative effective perceived noise level (EPNL) below the Stage 4 regulation. A suite of technologies that are deemed feasible to mature for practical implementation in the Far Term and whose potentials for noise reduction have been illustrated is selected for analysis. For each technology, component noise reduction is modeled either by available experimental data or by physics-based modeling with aircraft system level methods. The noise reduction is then applied to the corresponding noise component predicted by advanced aircraft system noise prediction tools, and the total aircraft noise is predicted as the incoherent summation of the components. It is shown that the Far Term MFN aircraft has the potential to achieve a cumulative noise level of 40.2 EPNL dB below Stage 4. The key technologies to achieve this low aircraft noise level are assessed by the impact of each technology on the aircraft system noise. This roadmap shows the potential of this revolutionary, yet still tube-and-wing, MFN concept to reach the NASA Far Term noise goal.