Simulated Space Radiation and Weightlessness: Vascular-Bone Coupling Mechanisms to Preserve Skeletal Health

Globus, R K ; Alwood, J ; Tahimic, C ; Schreurs, A-S ; Shirazi-Fard, Y ; Terada, M ; Zaragoza, J ; Truong, T ; Bruns, K ; Castillo, A(New York Univ, New York, NY, United States)

关键词: EXTRATERRESTRIAL RADIATION;    IONIZING RADIATION;    RADIATION EFFECTS;    SIMULATION;    WEIGHTLESSNESS SIMULATION;    EXPOSURE;    CARDIOVASCULAR SYSTEM;    BONES;    LOSSES;    MUSCULOSKELETAL SYSTEM;    OXIDATION;    STRESS (PHYSIOLOGY);    FLIGHT STRESS (BIOLOGY);    HINDLIMB SUSPENSION;    MICE;    MICROGRAVITY;    NASA SPACE PROGRAMS;   

RP-ID  :  ARC-E-DAA-TN38900

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来源: NASA Technical Reports Server

【 摘 要 】

We examined experimentally the effects of radiation and/or simulated weightlessness by hindlimb unloading on bone and blood vessel function either after a short period or at a later time after transient exposures in adult male, C57Bl6J mice. In sum, recent findings from our studies show that in the short term, ionizing radiation and simulate weightlessness cause greater deficits in blood vessels when combined compared to either challenge alone. In the long term, heavy ion radiation, but not unloading, can lead to persistent, adverse consequences for bone and vessel function, possibly due to oxidative stress-related pathways.