MRI-based Quantification of Optic Nerve Tortuosity and Subarachnoid Space 3D Geometry: Reliability Assessment

Rohr, Jesse J ; Sass, Austin M ; Sater, Stuart ; Stenger, Michael B ; Macias, Brandon R ; Ethier, C Roth ; Sargsyan, Ashot E ; Martin, Bryn A

关键词: BIOENGINEERING;    EUCLIDEAN GEOMETRY;    IMAGING TECHNIQUES;    MAGNETIC RESONANCE;    OPHTHALMOLOGY;    RELIABILITY ANALYSIS;    THREE DIMENSIONAL MODELS;    TRAJECTORIES;    ASTRONAUTS;    COMPUTERIZED SIMULATION;    HIGH RESOLUTION;    LENSES;    SHEATHS;    STANDARD DEVIATION;   

RP-ID  :  JSC-E-DAA-TN51611

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来源: NASA Technical Reports Server

【 摘 要 】

In some astronauts, long-duration space flight results in ophthalmic structure changes such as optic nerve (ON) kinking, ON distention, and globe flattening. Assessment of the ON and ON sheath (ONS) may provide insight into the mechanisms responsible for ophthalmic structure changes seen in a subset of astronauts. Automated and manual methods were developed to quantify 3D ON/ONS geometry and ON tortuosity.