DE-FG02-04ER63746 FinalTechnicalReport

Lidstrom, M.E.

University of Washington, Seattle, WA

关键词: Stresses;    Waste Processing;    Genes;    59 Basic Biological Sciences;    Biology;   

DOI  :  10.2172/963660
RP-ID  :  DOE ER63746-1
RP-ID  :  FG02-04ER63746
RP-ID  :  963660

美国|英语

来源: UNT Digital Library

【 摘 要 】

This is the final technical report for a project involving the study of stress response systems in the radiation-resistant bacterium, Deinococcus radiodurans. Three stresses of importance for a mixed waste treatment strain were studied, heat shock, solvent shock, and phosphate starvation. In each case, specific genes involved in the ability to survive the stress were identified using a systems biology approach, and analysis of mutants was used to understand mechanisms. This study has led to increased understanding of the ways in which a potential treatment strain could be manipulated to survive multiple stresses for treatment of mixed wastes.