LDRD Progress Report: Radioimmunotherapy using oxide nanoparticles: Radionuclide contaiment and mitigation of normal tissue toxicity.

Rondinone, Adam Justin ; Dai, Sheng ; Mirzadeh, Saed ; Kennel, Steve J

Oak Ridge National Laboratory

关键词: Leaching;    Radioimmunotherapy;    Antibodies;    Lungs;    Neoplasms;   

DOI  :  10.2172/930700
RP-ID  :  ORNL/TM-2005/539
RP-ID  :  DE-AC05-00OR22725
RP-ID  :  930700

美国|英语

来源: UNT Digital Library

【 摘 要 】

Radionuclides with specific emission properties can be incorporated into metal-chalcogenide and metal-oxide nanoparticles. Coupled to antibodies, these conjugates could be injected into the bloodstream to target and destroy non-solid tumors or target organs for radioimaging. In the first year of this project, two types of radioactive nanoparticles, CdTe: {sup 125m}Te and Y{sub 2}O{sub 3}: {sup 170}Tm were synthesized and coupled to antibodies specific to murine epithelial lung tissue. The nanoparticles successfully target the lung tissue in vivo. Some leaching of the radioisotope was observed. The coming year will explore other types of nanoparticles (other crystal chemistries) in order to minimize leaching.