Pentaerythritol Tetranitrate (PETN) Surveillance by HPLC-MS: Instrumental Parameters Development

Harvey, C A ; Meissner, R

Lawrence Livermore National Laboratory

关键词: Lawrence Livermore National Laboratory;    37 Inorganic, Organic, Physical And Analytical Chemistry;    Quadrupoles;    High-Performance Liquid Chromatography;    Mass Spectrometers;   

DOI  :  10.2172/886931
RP-ID  :  UCRL-TR-216908
RP-ID  :  W-7405-ENG-48
RP-ID  :  886931

美国|英语

来源: UNT Digital Library

【 摘 要 】

Surveillance of PETN Homologs in the stockpile here at LLNL is currently carried out by high performance liquid chromatography (HPLC) with ultra violet (UV) detection. Identification of unknown chromatographic peaks with this detection scheme is severely limited. The design agency is aware of the limitations of this methodology and ordered this study to develop instrumental parameters for the use of a currently owned mass spectrometer (MS) as the detection system. The resulting procedure would be a ''drop-in'' replacement for the current surveillance method (ERD04-524). The addition of quadrupole mass spectrometry provides qualitative identification of PETN and its homologs (Petrin, DiPEHN, TriPEON, and TetraPEDN) using a LLNL generated database, while providing mass clues to the identity of unknown chromatographic peaks.