Molecular Recognition of DNA Damage Sites by Apurinic/Apyrimidinic Endonucleases

Braun, W. A.

University of Texas Medical Branch, Galveston, TX

关键词: Dna Damages;    Apes;    Dna;    Ionizing Radiations;    59 Basic Biological Sciences;   

DOI  :  10.2172/877152
RP-ID  :  DOE/ER/63041-1
RP-ID  :  FG03-00ER63041
RP-ID  :  877152

美国|英语

来源: UNT Digital Library

【 摘 要 】

The DNA repair/redox factor AP endonuclease 1 (APE1) is a multifunctional protein which is known to to be essential for DNA repair activity in human cells. Structural/functional analyses of the APE activity is thus been an important research field to assess cellular defense mechanisms against ionizing radiation.