Sensor for cell signaling proteins.

Farrow, Matthew ; Yelton, William Graham

Sandia National Laboratories

关键词: Oxidation;    Monitoring;    Ferrocene;    Electrodes;    59 Basic Biological Sciences;   

DOI  :  10.2172/876383
RP-ID  :  SAND2005-7590
RP-ID  :  AC04-94AL85000
RP-ID  :  876383

美国|英语

来源: UNT Digital Library

【 摘 要 】

Thiolated cyclodextrins have been shown to be useful as modifiers of electrode surfaces for application in electrochemical sensing. The adsorption of three different thiolated {beta}-cyclodextrin ({beta}-CD) derivatives onto gold (Au) electrodes was studied by monitoring ferricyanide reduction and ferrocene carboxylic acid (FCA) oxidation at the electrode surface using cyclic voltammetry. Electrodes modified with the {beta}-CD MJF-69 derivative bound FCA within the CD cavity. The monolayer acted as a conducting layer with an increase in the oxidation current. On the other hand, the {beta}-CD layer inhibited the reduction of ferricyanide at the electrode surface since ferricyanide is larger than the cavity of the {beta}-CD derivative and thus unable to form an inclusion complex.