Linking Molecular Events to Cellular Responses at Low Dose Exposures

Weber, Thomas J. ; Colburn, Nancy H. ; Bowman, Michael K.

Pacific Northwest National Laboratory (U.S.)

关键词: 63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;    Neoplasms;    54 Environmental Sciences;    Radiations;    Risk Assessment;   

DOI  :  10.2172/833477
RP-ID  :  EMSP-69941--2000
RP-ID  :  833477

美国|英语

来源: UNT Digital Library

【 摘 要 】

The studies proposed in this project are to define thresholds in cell signaling pathways that are required for cellular transformation and may be targeted by low-dose radiation. Defining thresholds in transformation-related signal transduction pathways that are sensitive to low-dose radiation would be an important advancement in risk assessment and could be used to demonstrate nonlinear relationships between low-dose radiation and cancer.