Engineering Radioactive Stents for the Prevention of Restenosis

Thomadsen, Bruce ; Nickles, Robert J. ; DeWerd, Larry ; Henderson, Douglass ; Nye, Jonathan ; Culberson, Wes ; Peterson, Stephen ; Meltsner, Michael ; Lin, Liyong

University of Wisconsin--Madison

关键词: Calibration;    46 Instrumentation Related To Nuclear Science And Technology;    43 Particle Accelerators;    07 Isotopes And Radiation Sources;    Arteries;   

DOI  :  10.2172/831121
RP-ID  :  DOE/ID14107-3
RP-ID  :  FG07-01ID14107
RP-ID  :  831121

美国|英语

来源: UNT Digital Library

【 摘 要 】

Radiation has become an accepted treatment for the prevention of restenosis (re-blockage) of coronary arteries following angioplasty. Radioactive stents could be the easiest method of delivery for the radiation, although clinical trials were disappointing. One likely reason was the choice of P-32 as the radionuclide, which fails to match the biological needs of the problem. What radionuclide would perform best remains unknown. This project established the physical infrastructure necessary for a rational investigation to determine the optimum radiological characteristics for radioactive stents in the prevention of restenosis following angioplasty. The project investigated methods to activate coronary stents with radionuclides that spanned a range of energies and radiation types that could provide a mapping of the biological response. The project also provided calibration methods to determine the strength of the stents, an a process to calculate the dose distribution actually delivered to the patient's artery--quantities necessary for any future scientific study to improve the effectiveness of radioactive stents. Such studies could benefit the thousands of patients who receive angioplasty each year.