Genetic Engineering of a Radiation-Resistant Bacterium for Biodegradation of Mixed Wastes

Lidstrom, Mary E.

University of Washington

关键词: Genetics;    59 Basic Biological Sciences;    Genetic Engineering;    Wastes;    Detoxification;   

DOI  :  10.2172/828598
RP-ID  :  EMSP-60150--2000
RP-ID  :  FG07-97ER20294
RP-ID  :  828598

美国|英语

来源: UNT Digital Library

【 摘 要 】

The mixture of toxic chemicals, heavy metals, halogenated solvents and radionuclides in many DOE waste materials presents a challenging problem for separating the different species and disposing of individual contaminants. One approach for dealing with mixed wastes is to genetically engineer the radiation-resistant bacterium, Deinococcus radiodurans to survive in and detoxify DOE's mixed waste streams, and to develop process parameters for treating mixed wastes with such constructed strains. The goal for this project is to develop a suite of genetic tools for Deinococcus radiodurans and to use these tools to construct and test stable strains for detoxification of haloorganics in mixed wastes.