科技报告详细信息
Mechanisms of Enhanced Cell Killing at Low Doses: Implications for Radiation Risk | |
Johnston, Dr. Peter J. ; Wilson, Dr. George D. | |
Gray Cancer Institute (United States) | |
关键词: Cell Killing; Neoplasms; Cell Transformations; Low Dose Irradiation; Extrapolation; | |
DOI : 10.2172/816335 RP-ID : DOE/ER/62878 RP-ID : FG07-99ER62878 RP-ID : 816335 |
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美国|英语 | |
来源: UNT Digital Library | |
【 摘 要 】
We have shown that cell lethality actually measured after exposure to low-doses of low-LET radiation, is markedly enhanced relative to the cell lethality previously expected by extrapolation of the high-dose cell-killing response. Net cancer risk is a balance between cell transformation and cell kill and such enhanced lethality may more than compensate for transformation at low radiation doses over a least the first 10 cGy of low-LET exposure. This would lead to a non-linear, threshold, dose-risk relationship. Therefore our data imply the possibility that the adverse effects of small radiation doses (<10 cGy) could be overestimated in specific cases. It is now important to research the mechanisms underlying the phenomenon of low-dose hypersensitivity to cell killing, in order to determine whether this can be generalized to safely allow an increase in radiation exposure limits. This would have major cost-reduction implications for the whole EM program.【 预 览 】
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816335.pdf | 2281KB | download |