Monte Carol-Based Dosimetry of Beta-Emitters for Intravascular Brachytherapy

Choi, C.K.

Purdue Research Foundation (United States)

关键词: Radioisotopes;    Diseases;    Recommendations;    Geometry;    Water Intravascular Brachytherapy, Radiochromic Film Dosimetry, Monte Carlo Simulations;   

DOI  :  10.2172/798524
RP-ID  :  DOE/NEER/PURDUE-C03-02
RP-ID  :  FG07-99ID13782
RP-ID  :  798524

美国|英语

来源: UNT Digital Library

【 摘 要 】

Monte Carlo simulations for radiation dosimetry and the experimental verifications of the simulations have been developed for the treatment geometry of intravascular brachytherapy, a form of radionuclide therapy for occluded coronary disease (restenosis). Monte Carlo code, MCNP4C, has been used to calculate the radiation dose from the encapsulated array of B-emitting seeds (Sr/Y-source train). Solid water phantoms have been fabricated to measure the dose on the radiochromic films that were exposed to the beta source train for both linear and curved coronary vessel geometries. While the dose difference for the 5-degree curved vessel at the prescription point of f+2.0 mm is within the 10% guideline set by the AAPM, however, the difference increased dramatically to 16.85% for the 10-degree case which requires additional adjustment for the acceptable dosimetry planning. The experimental dose measurements agree well with the simulation results