Final Report for High Precision Short-Pulse Laser Ablation System for Medical Applications

Kim, B.M. ; Feit, M. ; Rubenchik, A. ; Marion, J.

Lawrence Livermore National Laboratory

关键词: Luminescence;    Feedback;    Ablation;    Water;    Lasers;   

DOI  :  10.2172/792650
RP-ID  :  UCRL-ID-138215
RP-ID  :  W-7405-Eng-48
RP-ID  :  792650

美国|英语

来源: UNT Digital Library

【 摘 要 】

During the three year LDRD funding period, we studied the ablation characteristics of biological tissues using ultrashort pulse lasers (USPL) with pulse widths varying from 100 femtoseconds to tens of picoseconds. During the first year, we performed extensive theoretical studies to develop an improved understanding of the USPL ablation process. Two optical signals were tested for feasibility of use in real-time feedback systems during high repetition rate ablation. In the second year, we devised a real-time, feedback-controlled USPL ablation system, based on luminescence, which may be useful for sensitive micro-spinal surgeries. Effective laser parameters were identified to reduce collateral damage. The final year of the project focused on quantification of the pressure pulse induced by USPL ablation of water surfaces representing biological tissues. Results of these studies were presented in invited talks at domestic and international conferences and numerous journal articles were published (see bibliography). This effort has increased our scientific understanding of physical processes important for the therapeutic biomedical application of ultrashort pulse lasers, and has taken the first steps toward practical realization of such applications.