Environmentally-Induced Malignancies: An In Vivo Model to Evaluate the Health Impact of Chemicals in Mixed Waste

Pallavicini, Maria

University of California San Francisco (United States)

关键词: Hydrocarbons;    63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;    Health Hazards;    Chemical Wastes;    Neoplasms;   

DOI  :  10.2172/792424
RP-ID  :  DOE/ER/62682
RP-ID  :  FG07-98ER62682
RP-ID  :  792424

美国|英语

来源: UNT Digital Library

【 摘 要 】

Occupational and environmental exposure to organic ligands, solvents, fuel hydrocarbons, and polychlorinated biphenyls are linked with increased risk of hematologic malignancies. DOE facilities and waste sites in the U.S. are contaminated with mixtures of potentially hazardous chemicals such as metals, organic ligands, solvents, fuel hydrocarbons, polychlorinated biphenyls and radioactive isotopes. A major goal of this project was to establish linkage between chemical/radiation exposure and induction of genomic damage in target populations with the capability to undergo transformation.