Microdosimetry for Boron Neutron Capture Therapy

Maughan, R.L. ; Kota, C.

Richard L. Maughan, Department of Radiation Oncology, University of Pennsylvania, 2400 Spruce St., Philadelphia, PA

关键词: Boron Neutron Capture Therapy;    Microdosimetry;    Epithermal Neutrons;    Radiobiological Effectiveness;    Microdosimetry Microdosimetry;   

DOI  :  10.2172/770637
RP-ID  :  None
RP-ID  :  FG02-96ER62217
RP-ID  :  770637

美国|英语

来源: UNT Digital Library

【 摘 要 】

The specific aims of the research proposal were as follows: (1) To design and construct small volume tissue equivalent proportional counters for the dosimetry and microdosimetry of high intensity thermal and epithermal neutron beams used in BNCT, and of modified fast neutron beams designed for boron neutron capture enhanced fast neutron therapy (BNCEFNT). (2) To develop analytical methods for estimating the biological effectiveness of the absorbed dose in BNCT and BNCEFNT based on the measured microdosimetric spectra. (3) To develop an analytical framework for comparing the biological effectiveness of different epithermal neutron beams used in BNCT and BNCEFNT, based on correlated sets of measured microdosimetric spectra and radiobiological data. Specific aims (1) and (2) were achieved in their entirety and are comprehensively documented in Jay Burmeister's Ph.D. dissertation entitled ''Specification of physical and biologically effective absorbed dose in radiation therapies utilizing the boron neutron capture reaction'' (Wayne State University, 1999). Specific aim (3) proved difficult to accomplish because of a lack of sufficient radiobiological data.