科技报告详细信息
Preliminary Authorization Basis Document For the Proposed Biological Safety Level 3 (BSL-3) Facility (B368) at Lawrence Livermore National Laboratory Revision 2
Altenbach, T ; Nguyen, S
Lawrence Livermore National Laboratory
关键词: Lawrence Livermore National Laboratory;    99 General And Miscellaneous//Mathematics, Computing, And Information Science;    Classification;    Documentation;    59 Basic Biological Sciences;   
DOI  :  10.2172/15015184
RP-ID  :  UCRL-TR-208837
RP-ID  :  W-7405-ENG-48
RP-ID  :  15015184
美国|英语
来源: UNT Digital Library
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【 摘 要 】

The Lawrence Livermore National Laboratory Integrated Safety Management (ISM) System Description (LLNL 2002) and the Task Plan for the Preparation of Authorization Basis Documentation for the proposed Biosafety Level 3 Laboratory at Lawrence Livermore National Laboratory (DOE 2002a) require a PABD be prepared for the proposed BSL-3 Facility. NNSA-OAK approval is required prior to its construction. This Preliminary Authorization Basis Documentation (PABD) formalizes and documents the hazard evaluation and its results for the Biosafety level 3 (BSL-3) facility. The PABD for the proposed BSL-3 facility provides the following information: (1) BSL-3 facility's site description; (2) general description of the BSL-3 facility and its operations; (3) identification of facility hazards; (4) generic hazard analysis; (5) identification of controls important to safety; and (6) safety management programs. The PABD characterizes the level of intrinsic potential hazard associated with a facility and provides the basis for its hazard classification. The hazard classification determines the level of safety documentation required and the level of review and approval for the safety analysis. The hazards of primary concern associated with the BSL-3 facility are biological. The hazard classification is determined by comparing facility inventories of biological materials and activities with the BSL-3 threshold established by the Centers for Disease Control and Prevention (CDC) and the National Institutes of Health (NIH) for BSL-3 facilities.

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