Lattice Boltzmann Simulation of Particle Laden Flows in Microfluidic Systems

Clague, D S ; Weisgraber, T ; Wheeler, E ; Hon, G ; Radford, J ; Gascoyne, P ; Smity, R ; Liepmann, D ; Meinhart, C ; Santiago, J ; Krulevitch, P

Lawrence Livermore National Laboratory

关键词: Neoplasms;    42 Engineering;    Particulates;    Transport;    Simulation;   

DOI  :  10.2172/15004866
RP-ID  :  UCRL-ID-137061
RP-ID  :  W-7405-ENG-48
RP-ID  :  15004866

美国|英语

来源: UNT Digital Library

【 摘 要 】

The goal of this effort was to develop dynamic simulation tools to study and characterize particulate transport in Microfluidic devices. This includes the effects of external fields and near-field particle-particle, particle-surface interactions. The unique aspect of this effort is that we focused on the particles in suspension and rigorously accounted for all of the interactions that they experienced in solution. In contrast, other numerical methods within the program, finite element and finite volume approaches, typically treat the suspended species as non-interacting point particles. Later in the program, some of these approaches incorporated approximations to begin to account for particle-particle interactions. Through the programs (BioFlips and SIMBIOSYS), we developed collaborative relationships with device-oriented efforts. More specifically and at the request of the SIMBIOSYS program manager, we allowed our efforts/milestones to be more guided by the needs of our BioFlips colleagues; therefore, our efforts were focused on the needs of the MD Anderson Cancer Center (Peter Gascoyne), UCDavis (Rosemary Smith), and UC Berkeley (Dorian Liepmann). The first two collaborations involved the development of Dielectrophoresis analysis tools and the later involved the development of suspension and fluid modeling tools for microneedles.