科技报告详细信息
Year 2 Report: Protein Function Prediction Platform
Zhou, C E
Lawrence Livermore National Laboratory
关键词: Protein Structure;    Modifications;    Forecasting;    Functionals;    59 Basic Biological Sciences;   
DOI  :  10.2172/1043635
RP-ID  :  LLNL-TR-554191
RP-ID  :  W-7405-ENG-48
RP-ID  :  1043635
美国|英语
来源: UNT Digital Library
PDF
【 摘 要 】

Upon completion of our second year of development in a 3-year development cycle, we have completed a prototype protein structure-function annotation and function prediction system: Protein Function Prediction (PFP) platform (v.0.5). We have met our milestones for Years 1 and 2 and are positioned to continue development in completion of our original statement of work, or a reasonable modification thereof, in service to DTRA Programs involved in diagnostics and medical countermeasures research and development. The PFP platform is a multi-scale computational modeling system for protein structure-function annotation and function prediction. As of this writing, PFP is the only existing fully automated, high-throughput, multi-scale modeling, whole-proteome annotation platform, and represents a significant advance in the field of genome annotation (Fig. 1). PFP modules perform protein functional annotations at the sequence, systems biology, protein structure, and atomistic levels of biological complexity (Fig. 2). Because these approaches provide orthogonal means of characterizing proteins and suggesting protein function, PFP processing maximizes the protein functional information that can currently be gained by computational means. Comprehensive annotation of pathogen genomes is essential for bio-defense applications in pathogen characterization, threat assessment, and medical countermeasure design and development in that it can short-cut the time and effort required to select and characterize protein biomarkers.

【 预 览 】
附件列表
Files Size Format View
1043635.pdf 1617KB PDF download
  文献评价指标  
  下载次数:20次 浏览次数:32次