Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.

Kaehr, Bryan James

Sandia National Laboratories

关键词: Functionals;    59 Basic Biological Sciences;    Biology;    Design;    Chemistry;   

DOI  :  10.2172/1029826
RP-ID  :  SAND2011-6892
RP-ID  :  AC04-94AL85000
RP-ID  :  1029826

美国|英语

来源: UNT Digital Library

【 摘 要 】

This is the final report for the President Harry S. Truman Fellowship in National Security Science and Engineering (LDRD project 130813) awarded to Dr. Bryan Kaehr from 2008-2011. Biological chemistries, cells, and integrated systems (e.g., organisms, ecologies, etc.) offer important lessons for the design of synthetic strategies and materials. The desire to both understand and ultimately improve upon biological processes has been a driving force for considerable scientific efforts worldwide. However, to impart the useful properties of biological systems into modern devices and materials requires new ideas and technologies. The research herein addresses aspects of these issues through the development of (1) a rapid-prototyping methodology to build 3D bio-interfaces and catalytic architectures, (2) a quantitative method to measure cell/material mechanical interactions in situ and at the microscale, and (3) a breakthrough approach to generate functional biocomposites from bacteria and cultured cells.