Viscoelastic Model for Lung Parenchyma for Multi-Scale Modeling of Respiratory System Phase I: Hypo-Elastic Model for CFD Implementation

Freed, Alan D. ; Einstein, Daniel R.

Pacific Northwest National Laboratory (U.S.)

关键词: 99 General And Miscellaneous//Mathematics, Computing, And Information Science;    Lungs;    Implementation;    59 Basic Biological Sciences;    Simulation;   

DOI  :  10.2172/1013297
RP-ID  :  PNNL-20340
RP-ID  :  AC05-76RL01830
RP-ID  :  1013297

美国|英语

来源: UNT Digital Library

【 摘 要 】

An isotropic constitutive model for the parenchyma of lung has been derived from the theory of hypo-elasticity. The intent is to use it to represent the mechanical response of this soft tissue in sophisticated, computational, fluid-dynamic models of the lung. This demands that the continuum model be accurate, yet simple and effcient. An objective algorithm for its numeric integration is provided. The response of the model is determined for several boundary-value problems whose experiments are used for material characterization. The effective elastic, bulk, and shear moduli, and Poisson’s ratio, as tangent functions, are also derived. The model is characterized against published experimental data for lung. A bridge between this continuum model and a dodecahedral model of alveolar geometry is investigated, with preliminary findings being reported.