Introduction. Laser pointers have been used for years to highlight key areas on charts and screens during visual presentations. When used in a responsible manner, laser pointers are not considered hazardous. While momentary ocular exposure to the light emitted by these devices can be startling to the observer and may result in temporary visual impairment, such exposures are too brief to cause any permanent ocular injury. However, as the availability of laser pointers has increased, so have reports of their misuse by some children and adults. In recent years, both the Food and Drug Administration and the American Academy of Ophthalmology have issued warnings concerning the possibility of eye injury from handheld laser pointers and recommended keeping these devices away from children. The purpose of this report was to investigate the illumination of aircraft by laser pointers in the National Airspace System.Case Reports. From January 1996 to July 1999, the FAA�s Western-Pacific Region identified more than 150 incidents in which low-flying aircraft were illuminated by lasers. Laser pointers were used in the majority of these incidents, and there were several occurrences of visual impairment to the pilot. Representative examples of documented reports are presented that involved the illumination of civilian flight crewmembers by these hand-held devices.Conclusions. Laser pointers have caused ocular injury and may compromise aviation safety when used to illuminate aircraft in critical phases of flight. The physiological effects of exposure to laser light and the regulation and classification of commercial laser products are discussed. The proper selection and use of these devices can minimize the threat of temporary incapacitation and eye injury.