Piezoelectric inkjet technology is critical to documentation, graphic arts and manufacturing applications. Physical modeling plays an essential role in the development of this technology. In this paper, we present a comprehensive, multi-level, inter- disciplinary simulation approach for piezoelectric inkjet design. This includes a high-fidelity, interdisciplinary detailed simulation method for architecture investigation, and a much faster reduced- order modeling approach that enables interactive design of voltage waveforms. Simulation results are compared with experimental data. The multi-level inter-disciplinary simulation methodology presented here can be applied to designing MEMS and microfluidic devices and systems [1].