Particle compositions with a pre-selected cell internalization mode

Decuzzi, Paolo ; Ferrari, Mauro

PID  :  NTRS Document ID: 20120009596

学科分类：自然科学（综合）

美国|英语

来源: NASA Technical Reports Server

【 摘 要 】

A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the surface receptors of the cell and ii) a preselected shape, where a surface distribution of the surface moieties on the particles and the shape of the particles are effective for the pre-selected cell internalization mode.